Serum lipofuscin as a prognostic indicator of adult respiratory distress syndrome and multiple organ failure
Identifieur interne : 002C67 ( Main/Exploration ); précédent : 002C66; suivant : 002C68Serum lipofuscin as a prognostic indicator of adult respiratory distress syndrome and multiple organ failure
Auteurs : R. M. H. Roumen [Pays-Bas] ; Th. Hendriks [Pays-Bas] ; B. M. De Man [Pays-Bas] ; R. J. A. Goris [Pays-Bas]Source :
- British Journal of Surgery [ 0007-1323 ] ; 1994-09.
Abstract
Toxic oxygen free radical damage is thought to play an important role in events such as trauma and sepsis, in which adult respiratory distress syndrome (ARDS) and multiple organ failure (MOF) are the major causes of late death. Serum lipofuscin concentration has been proposed as an indicator of lipid peroxidation caused by toxic oxygen free radicals. Serum lipofuscin level was measured in 75 healthy controls and sequentially in 66 patients in the intensive care unit; the latter included 18 patients who had undergone elective major vascular surgery, 20 after repair of ruptured abdominal aortic aneurysm and 28 with severe blunt trauma. Fifteen of the 66 patients died within 2 days. Ten of the remaining 51 patients developed ARDS and/or MOF and 41 had an uncomplicated postoperative course. Serum lipofuscin concentration in controls showed a positive correlation with age. Compared with controls, all three patient groups had significantly increased lipofuscin concentrations during the first day after major vascular surgery, trauma or shock. In addition, the ten patients who subsequently developed ARDS and/or MOF showed significantly increased lipofuscin levels on day 1, compared with those in the 41 who had an uncomplicated clinical course. The concentration of serum lipofuscin, which may act as a simple and valuable measure of grading oxidative stress, is positively related to the incidence of subsequent ARDS and/or MOF in patients at risk of these syndromes.
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DOI: 10.1002/bjs.1800810913
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Hendriks</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgery, University Hospital Nijmegen, Geert Grooteplein 14, PO Box 9101, 6500‐HB Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="De Man, B M" sort="De Man, B M" uniqKey="De Man B" first="B. M." last="De Man">B. M. De Man</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgery, University Hospital Nijmegen, Geert Grooteplein 14, PO Box 9101, 6500‐HB Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Goris, R J A" sort="Goris, R J A" uniqKey="Goris R" first="R. J. A." last="Goris">R. J. A. Goris</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgery, University Hospital Nijmegen, Geert Grooteplein 14, PO Box 9101, 6500‐HB Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">British Journal of Surgery</title><title level="j" type="alt">BRITISH JOURNAL OF SURGERY</title><idno type="ISSN">0007-1323</idno><idno type="eISSN">1365-2168</idno><imprint><biblScope unit="vol">81</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1300">1300</biblScope><biblScope unit="page" to="1305">1305</biblScope><biblScope unit="page-count">6</biblScope><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Bristol</pubPlace><date type="published" when="1994-09">1994-09</date></imprint><idno type="ISSN">0007-1323</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0007-1323</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Toxic oxygen free radical damage is thought to play an important role in events such as trauma and sepsis, in which adult respiratory distress syndrome (ARDS) and multiple organ failure (MOF) are the major causes of late death. Serum lipofuscin concentration has been proposed as an indicator of lipid peroxidation caused by toxic oxygen free radicals. Serum lipofuscin level was measured in 75 healthy controls and sequentially in 66 patients in the intensive care unit; the latter included 18 patients who had undergone elective major vascular surgery, 20 after repair of ruptured abdominal aortic aneurysm and 28 with severe blunt trauma. Fifteen of the 66 patients died within 2 days. Ten of the remaining 51 patients developed ARDS and/or MOF and 41 had an uncomplicated postoperative course. Serum lipofuscin concentration in controls showed a positive correlation with age. Compared with controls, all three patient groups had significantly increased lipofuscin concentrations during the first day after major vascular surgery, trauma or shock. In addition, the ten patients who subsequently developed ARDS and/or MOF showed significantly increased lipofuscin levels on day 1, compared with those in the 41 who had an uncomplicated clinical course. The concentration of serum lipofuscin, which may act as a simple and valuable measure of grading oxidative stress, is positively related to the incidence of subsequent ARDS and/or MOF in patients at risk of these syndromes.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Gueldre</li></region><settlement><li>Nimègue</li></settlement></list><tree><country name="Pays-Bas"><region name="Gueldre"><name sortKey="Roumen, R M H" sort="Roumen, R M H" uniqKey="Roumen R" first="R. M. H." last="Roumen">R. M. H. Roumen</name></region><name sortKey="De Man, B M" sort="De Man, B M" uniqKey="De Man B" first="B. M." last="De Man">B. M. De Man</name><name sortKey="Goris, R J A" sort="Goris, R J A" uniqKey="Goris R" first="R. J. A." last="Goris">R. J. A. Goris</name><name sortKey="Hendriks, Th" sort="Hendriks, Th" uniqKey="Hendriks T" first="Th." last="Hendriks">Th. Hendriks</name><name sortKey="Roumen, R M H" sort="Roumen, R M H" uniqKey="Roumen R" first="R. M. H." last="Roumen">R. M. H. Roumen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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